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1.
West Indian med. j ; 55(4): 274-278, Sept. 2006.
Article in English | LILACS | ID: lil-472119

ABSTRACT

The objective of the present study is to evaluate the beneficial effect of tomatoes, which are a rich source of lycopene, a relatively new carotenoid known to play an important role in human health. In this study, the lipid peroxidation rate was investigated by estimating malondialdehyde (TBARS) levels of antioxidant enzymes like SOD, GSH-Px, GR, GSH, lipid profile, which includes total cholesterol, triglycerides, high density lipoprotein, low density lipoprotein, very low density lipoprotein, and glycated haemoglobin HbA1c in (n = 40) the Type 2 diabetic group (n = 40) and an age-matched control group (n = 50). Significantly lower levels of antioxidant enzymes and very high lipid peroxidation rate in the Type 2 diabetic group were observed when compared to controls (p 0.10). These findings suggest that tomato lycopene may have considerable therapeutic potential as an antioxidant but there was no significant lipid lowering effect in Type 2 diabetes mellitus.


El objetivo del presente estudio es evaluar el efecto beneficioso del tomate como fuente rica en licopeno – un carotenoide relativamente nuevo, del cual se sabe que juega un importante papel en la salud humana. En este estudio, investigamos el índice de peroxidación lipídica, estimando los niveles MDA (TBARS) de las enzimas antioxidantes como SOD, GSH-Px, GR, GSH, el perfil lipídico, que incluye el colesterol total, los triglicéridos, los HDL, LDL, VLDL, y la hemoglobina glicada (HbA1c) en (n = 40) en el grupo diabético tipo 2 (n = 40) y el grupo de control pareado por edad (n = 50). En este estudio, observamos niveles significativamente más bajos de enzimas antioxidantes e índices de peroxidación lipídica muy altos en el grupo diabético tipo 2, en comparación con el grupo control (p < 0.001). Asimismo observamos niveles significativamente más altos de perfil lipídico y hemoglobina glicada (HbA1c) en el grupo diabético al comparársele con el grupo control (p < 0.001).


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Antioxidants , Carotenoids/pharmacology , /metabolism , Lipids , Solanum lycopersicum/chemistry , Lipid Peroxidation/drug effects , Dietary Supplements , Carotenoids/therapeutic use , /physiopathology , Oxidative Stress/drug effects , Case-Control Studies , Time Factors , Glycated Hemoglobin/drug effects
2.
3.
J Indian Med Assoc ; 1975 Mar; 64(6): 160-1
Article in English | IMSEAR | ID: sea-101888
5.
J Indian Med Assoc ; 1974 Aug; 63(3): 104
Article in English | IMSEAR | ID: sea-97905
7.
J Indian Med Assoc ; 1970 Apr; 54(7): 328-9
Article in English | IMSEAR | ID: sea-104027
9.
J Indian Med Assoc ; 1965 Aug; 45(3): 149-50
Article in English | IMSEAR | ID: sea-101152
11.
J Indian Med Assoc ; 1964 Jun; 42(): 576-8
Article in English | IMSEAR | ID: sea-106102
12.
J Indian Med Assoc ; 1964 Apr; 42(): 339-40
Article in English | IMSEAR | ID: sea-97053
13.
J Indian Med Assoc ; 1964 Jan; 42(): 35
Article in English | IMSEAR | ID: sea-104120
14.
J Indian Med Assoc ; 1962 Dec; 39(): 621-7
Article in English | IMSEAR | ID: sea-105773

Subject(s)
Sarcoma, Synovial
15.
J Indian Med Assoc ; 1962 Nov; 39(): 470-3
Article in English | IMSEAR | ID: sea-102291

Subject(s)
Bone Neoplasms
16.
J Indian Med Assoc ; 1962 Nov; 39(): 470-3
Article in English | IMSEAR | ID: sea-100695

Subject(s)
Bone Neoplasms
17.
J Indian Med Assoc ; 1961 Nov; 37(): 448-9
Article in English | IMSEAR | ID: sea-96217
18.
J Indian Med Assoc ; 1959 Dec; 33(): 464-8
Article in English | IMSEAR | ID: sea-103170
19.
J Indian Med Assoc ; 1959 Aug; 33(): 97-8
Article in English | IMSEAR | ID: sea-104149
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